Dopamine: receptor families, clearance and pathways

The system behind reward, motivation, movement and psychosis — and the main target of antipsychotics and many drugs of abuse.

Dónde encajaSe conecta con 2 · Desbloquea 1

Se conecta con: Where drugs act: the brain's regions — Pathways connect the VTA, nucleus accumbens, cortex, substantia nigra and striatum.
Making neurotransmitters: precursors and rate-limiting steps — Made from tyrosine; L-DOPA shortcuts synthesis.
Desbloquea: Norepinephrine and serotonin — and serotonin syndrome — Norepinephrine is made from dopamine and shares MAO and COMT.

Orientarse

Dopamine (DA) – a catecholamine and a monoamine (monoamine = one amino acid group). DA receptors – all metabotropic: D1 family (excitatory) and D2 family (inhibitory). Metabolized by MAO (monoamine oxidase) and COMT; reuptaken by DAT (dopamine transporter). Three pathways: mesolimbic (the “reward” pathway, VTA to nucleus accumbens), mesocortical and nigrostriatal.

Términos del curso

Las palabras de tu profesor, tal cual aparecen en las diapositivas. Aprende el término y esta definición; la explicación de abajo solo ayuda a entenderla.

Monoamine: “Monoamine = one amino acid group”Diapositivas 03, p. 21
Dopamine, norepinephrine and serotonin; catecholamines (DA, NE) and indolamines (5-HT).
Monoamine oxidase (MAO): “Monoamines are metabolized by the enzyme monoamine oxidase (MAO)”Diapositivas 03, p. 21
“This is one to remember!”
D1 family: “D1 family (excitatory)”Diapositivas 03, p. 23
D1 and D5.
D2 family: “D2 family (inhibitory)”Diapositivas 03, p. 23
D2, D3, D4.
DAT: “reuptaken by DAT (dopamine transporter)”Diapositivas 03, p. 23
Also metabolized by MAO and COMT (catechol-O-methyltransferase).
Mesolimbic pathway: ““Reward” pathway”Diapositivas 03, p. 24
Ventral tegmental area (VTA) to nucleus accumbens – acute reward; positive symptoms of schizophrenia associated.
Mesocortical pathway: “Focus and attention; working memory”Diapositivas 03, p. 24
Negative symptoms of schizophrenia associated.
Nigrostriatal pathway: “Nigrostriatal/mesostriatal pathway”Diapositivas 03, p. 24
Movement; damaged in Parkinson's.

De tu curso: Course slides 03, pp. 21–24

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Lección completa: Dopamine families and pathways