ADME: the drug's journey through the body

The overview map of pharmacokinetics: four processes that decide how much drug reaches the brain, when, and for how long.

Dónde encajaSe conecta con 1 · Desbloquea 4

Se conecta con: The two journeys: pharmacokinetics and pharmacodynamics — This is journey 1 — what the body does to the drug.
Desbloquea: Absorption and routes of administration — Zoom into A: absorption and routes.
Distribution: membranes, protein binding and barriers — Zoom into D: distribution and barriers.
Metabolism and excretion: the liver and kidneys — Zoom into M: metabolism.
Half-life and redistribution — All four together set half-life and duration.

Orientarse

Pharmacokinetics has four processes (ADME). Absorption – movement of drug from administration site into the bloodstream. Distribution – movement of drug through blood to rest of body (especially the brain). Metabolism – breakdown of drug by enzymes to prepare for elimination. Elimination – removal of drug itself or metabolic waste products from the body.

Términos del curso

Las palabras de tu profesor, tal cual aparecen en las diapositivas. Aprende el término y esta definición; la explicación de abajo solo ayuda a entenderla.

Absorption: “Movement of drug from administration site into the bloodstream”Diapositivas 04, p. 3
The A of ADME.
Bioavailability: “Bioavailability: % of original dose taken that is successfully absorbed into bloodstream”Diapositivas 04, p. 3
IV drugs have 100% bioavailability by this definition.
Distribution: “Movement of drug through blood to rest of body”Diapositivas 04, p. 3
Including how well (and if) the drug crosses the blood-brain barrier.
Metabolism: “Breakdown of drug by enzymes to prepare for elimination”Diapositivas 04, p. 3
Some drugs are excreted intact.
Elimination: “Removal of drug itself or metabolic waste products from the body”Diapositivas 04, p. 3
Excretion.

De tu curso: Course slides 04, pp. 2–4

Consejo: las teclas ← y → recorren la lección.

Lección completa: Pharmacokinetics and ADME